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KMID : 0620920070390020176
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Experimental & Molecular Medicine
2007 Volume.39 No. 2 p.176 ~ p.184
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CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR z
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Oh Kwon-Ik
Kim Byoung-Kwon
Ban Young-Larn
Choi Eun-Young
Chung Kyung-Chun
Lee Im-Soon
Park Seong-Hoe
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Abstract
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We investigated the co-stimulatory role of a cell- surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR z-mediated signal 1. These data demonstrate the unique properties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident co- stimulatory factors.
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KEYWORD
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antigens, lymphocyte activation, receptors, antigen, T-cell, signal transduction, T lymphocytes
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